David Linn Associate Professor
Biomedical Science Department 229 Padnos Hall or 560 CHS Allendale, Michigan 49401 Phone: 616-331-8709 or 331-5880
email: email@example.com OFFICE HOURS:
See available times here,
or by appointment
Post Doc: LSU Eye Center, New Orleans, LA Post Doc: Moran Eye Center, Salt Lake City, UT Ph.D. - University of Texas, Houston Medical Center M.S. Rice University, Houston,TX RESEARCH INTERESTS
My main area of research at GVSU has been the visual system. We have been exploring the mechanisms of action of excitatory neurotransmitters including glutamate and acetylcholine (ACh) in the mammalian retina. Over the years, and particularly during my time at Pharmacia & Upjohn / Pfizer, my research has shifted towards the function of ACh once released in the retina. Some of our work supports the concept that ACh activates receptors (i.e. alpha7 nicotinic) on retinal ganglion cells, and these receptors could be involved in activating survival mechanisms during pathological states (e.g. glaucoma). The retinal ganglion cells are the targets of neurodegeneration during glaucoma & our work is directed at potential therapies that might provide neuroprotection during glaucoma.
Linn DM & Wong EH-F (5/13/2004) 'NICOTINIC ACETYLCHOLINE AGONISTS IN THE TREATMENT OF GLAUCOMA AND RETINAL NEUROPATHY' WO2004039366
SELECTED PUBLICATIONS Asomugha CO, Linn DM and Linn CL (2009) ACh receptors link two signaling pathways to neuroprotection against glutamate-induced excitotoxicity in isolated pig RGCs. Journal of Neurochemistry, 112(1): 214 - 225.
Thompson SA, Smith O, Linn DM and Linn CL (2006) Acetylcholine neuroprotection against glutamate-induced excitotoxicity in adult pig retinal ganglion cells is partially mediated through alpha4 nicotinic acetylcholine receptors. Experimental Eye Research 83(5):1135-45. Wehrwein E, Thompson SA, Coulibaly SF, Linn DM and Linn CL (2004) Acetylcholine protects isolated adult pig retinal ganglion cells from glutamate-induced excitotoxicity. Investigative Ophthalmology and Visual Science 45(5): 1531-1543. Boudaba C, Linn DM, Halmos CS and Tasker JG (2003) Increased tonic activation of presynaptic metabotropic glutamate receptors in the rat supraoptic nucleus following chronic dehydration. Journal of Physiology (London) 551(3): 815-823. Fanscik A, Linn DM and Tasker JG (2000) Neurosteroid modulation of GABA IPSCs is phosphorylation dependent. Journal of Neuroscience 20(9): 3067-3075. Solessio E, Linn DM, Perlman I and Lasater EM (2000) A characterization with intracellular barium of potassium currents in turtle Müller cells. Journal of Neurophysiology 83: 418-430. Linn DM (1998) A comparison of the inhibitory actions of glycine and GABA on ACh release from the rabbit retina. Visual Neuroscience 15: 1057-1065.