Associate Professor Biomedical Science Department 221 Padnos Allendale, MI 49401
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Postdoctoral fellow, Medical College of Wisconsin, 2002
PhD (Physiology) Medical College of Wisconsin, 2002 M.A. (Biology) Drake University, 1997 B.S. (Animal Science) Cornell University, 1993
Our laboratory studies alterations in the function of blood vessels in response to changes in diet and the environment. I am most interested in deciphering the changes in blood flow regulation within the circulation at different levels of spatial resolution. This area of research utilizes multiple experimental techniques including in vitro and in situ tissue preparations, protein expression and function assays, and whole animal instrumentation. My earlier work utilized genetic and experimental models of hypertension to study the role of cardiovascular control mechanisms in the development and maintenance of high blood pressure. More recently, our work has focused on the effect of hyperbaric oxygen treatment on vascular control mechanisms. These studies are designed to characterize the altered responses of various blood vessels to different stimuli following exposure to hyperbaric conditions. It is hoped that insight gained from these studies may lead to an improved understanding of the expanding role of hyperbaric therapy in a clinical setting.
1. F.A. Sylvester, J.C. Frisbee, and J.H. Lombard. Longitudinal differences in vascular control mechanisms in isolated resistance arteries of the rat cremaster muscle. Microvasc. Res. 60:160-167, 2000.
2. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. Contribution of extrinsic factors and intrinsic vascular alterations to reduced arteriolar reactivity with high salt diet and hypertension. Microcirculation. 7:281-289, 2000.
3. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. High-salt diet impairs hypoxia-induced cAMP production and hyperpolarization in rat skeletal muscle arteries. Am. J. Physiol. 281:H1808-H1815, 2001.
4. F.A. Sylvester, D.W. Stepp, J.C. Frisbee, and J.H. Lombard. High-salt diet depresses acetylcholine reactivity proximal to NOS activation in cerebral arteries. Am. J. Physiol. 283:H353-H363, 2002.
5. J.H. Lombard, F.A. Sylvester, S.A. Phillips, and J.C. Frisbee. High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. Am. J. Physiol. 284:H1124-H1133, 2003.
6. S.A. Phillips, F.A. Sylvester, and J.C. Frisbee. Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats. Am. J. Physiol. 288:R522-530, 2005.