Michael Peruzzi ACF Abstract FY12

"Investigation of Carbamoylmethyl Phosphine Gadolinium Chelating Agents"

Conference Name: Argonne Undergraduate Symposium

Michael T. Peruzzi1, Charles F. DeLisle1, Shannon M. Biros*1, Eric J. Werner2, Grand Valley State University1, Department of Chemistry, Allendale, MI 49401, The University of Tampa2, Department of Chemistry & Physics, Tampa, FL, biross@gvsu.edu.

One method of Medical Resonance Imaging (MRI) is to use Gadolinium (Gd) metal as a contrast agent to achieve high quality images used for making a diagnosis or treating a disease. However Gd is toxic to the human body which makes a chelating agent necessary to prevent harm to patients undergoing an MRI procedure. An ideal chelating agent is water soluble, stable, and increases the relaxivity rates of nearby water molecules. Our lab is developing several chelating agents using a carbamoylmethyl phosphine oxide (CMPO) motif. Several facets of potential agents are being explored to determine how chelation of the Gd, or other potential metals, can be maximized. Some of these aspects include varying the side groups of the CMPO ligands, number of carbon atoms in the scaffolding, positioning of lone pair electrons on the cap of the chelating agent, and the functionality of the cap itself.