Osman Patel, Ph.D.

osman

Professor of CMB

3361 KHS

Phone: (616) 331-2470

Email: [email protected]

Office Hours:

Education

Ph D (Vet. Med.) University of Tokyo

Master's (Vet. Med.) University of Glasgow

Bachelor's (Vet. Med.) University of Zambia

 

Research Experience-Postdoctoral Fellow

2000-2002 Laboratory of Reproductive Biology and Technology, National Institute of Agrobiological Sciences, Tsukuba, Japan

2003-2008 Department of Animal Sciences, Michigan State University, East Lansing, USA

 

Courses taught:

CMB 610 (Foundations of Biotechnology)

CMB 620 (Techniques in Cell and Tissue Culture)

CMB 680 (Scientific Communication)

BIO 325 (Human Sexuality)

BIO 328 (Biomedical Ethics)

CMB 406 (Cell and Molecular Biology Laboratory)

HNR 311 (Biotechnology and The World)

 

Research interests:

My broad research interests lie in understanding:

  1. Endocrine, metabolic and molecular interactions coordinating physiological (homeostatic/homeorhetic) adaptation in key metabolic tissues during pregnancy and lactation, and delineating the aberrations induced by exposure to altered gravity.

  2. The biochemical and molecular constituents of an oocyte/embryo endowed with capacity to develop. Specifically, identify constituents that can aid in predicting developmental capacity and serve as reliable selection markers for assisted reproductive technologies.

  3. Molecular and cellular developmental chronology of a placenta, in particular, the cross-talk at the fetal, maternal and placental interface.

 

Peer-reviewed Publications:

  1. Patel OV, Casey T., Plaut K. Profiling solute-carrier transporters in key metabolic tissues during the postpartum evolution of mammary epithelial cells from non-secretory to secretory. Physiol. Genomics 2019 (Special Issue: Physiology of Cell State Transitions), 51(11), 539.

  2. Casey T, Patel OV, Plaut K. Transcriptomes reveal alterations in gravity impact circadian clocks and activate mechanotransduction pathways with adaptation through epigenetic change. Physiol Genomics 2015, 47(4): 113.

  3. Patel OV, Casey T, Dover H, Plaut K. Homeorhetic adaptation to lactation: comparative transcriptome analysis of mammary, liver, and adipose tissue during the transition from pregnancy to lactation in rats. Funct Integr Genomics 2011, 11: 193.

  4. Casey T, Patel O, Dykema K, Dover H, Furge K, Plaut K. Molecular signatures reveal circadian clocks may orchestrate the homeorhetic response to lactation. PLos ONE 2009, 4(10): e7395.

  5. Nakaya Y, Kizaki K, Takahashi T, Patel OV, Hashizume K. Characterization of DNA methylation-mediated regulation of bovine placental lactogen and bovine prolactin-related protein-1 gene. BMC Mol Biol 2009, 10:19.

  6. Casey T, Bond J, Tighe S, Hunter T, Lintault L, Patel O, Eneman J, Crocker A, White J, Tessitore J, Stanley M, Harlow S, Weaver D, Muss H, Plaut K. Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer. Breast Cancer Res. Treat. 2009, 114:47

  7. Patel OV, Zakrzewska E, Maple RL, Baer L, Ronca A, Wade C, Plaut K. Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion. Eur. J. Appl. Physiol. 2008, 104: 847.

  8. Bettegowda A, Patel OV, Lee KB, Park KE, Salem M, Yao J, Ireland JJ, Smith GW. Identification of novel bovine cumulus cell molecular markers predictive of oocyte competence: functional and diagnostic implications. Biol. Reprod. 2008, 79: 301.

  9. Patel OV, Maple R, Bear L, Ronca A., Wade C. and Plaut K. Tissue-specific variation in expression of prolactin receptor gene subtypes in hypergravity-exposed rats. J. Gravit. Physiol. 2007, 14: 129.

  10. Patel OV, Bettegowda A, Ireland JJ, Coussens PM, Lonergan P, Smith GW. Functional genomics studies of oocyte competence: Evidence that reduced transcript for follistatin is associated with poor developmental competence of bovine oocyte. Reprod 2007, 133: 95.

  11. Bettegowda A, Yao J, Sen A, Li Q, Lee KB, Kobayashi Y, Patel OV, Coussens PM, Ireland JJ, Smith GW. JY-1, an oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle. Proc Natl Acad Sci U S A. 2007, 104:17602.

  12. Hashizume K, Ushizawa K, Patel OV, Kizaki K, Imai K, Yamada O, Nakano H, Takahashi T. Gene expression and maintenance of pregnancy in bovine: roles of trophoblastic binucleate cells-specific molecules. Reprod Fert Dev 2007, 19: 79.

  13. Samma P, Patel OV, Bettegowda A, Ireland JJ, Smith GW. A novel algorithm for transcriptome analysis. Physiol Genomics 2006, 28: 62.

  14. Corcoran D, Fair T, Park S, Rizos D, Patel OV, Smith GW, Coussens PM, Ireland JJ, Boland MP, Evans ACO, Lonergan P. Suppressed Expression of Genes Involved In Transcription And Translation In In Vitro Compared To In Vivo Cultured Bovine Embryos. Reprod 2006, 131: 651.

  15. Bettegowda A, Patel OV, Ireland JJ, Smith GW. Quantitative Analysis of Messenger RNA Abundance for Ribosomal Protein L-15, Cyclophilin-A, Phosphoglycerokinase, β-glucuronidase, Glyceraldehyde 3-Phosphate Dehydrogenase, β-Actin and Histone H2A during Bovine Oocyte Maturation and Early Embryogenesis In Vitro. Mol Reprod Dev. 2006, 73:267.

  16. Patel OV, Suchyta S, Sipkovsky SS, Yao J, Ireland JJ, Coussens PM, Smith GW. Validation and application of a high-fidelity mRNA linear amplification procedure for profiling gene expression. Vet Immunol Immunopath 2005, 105: 331.

  17. Patel OV, Takahashi T, Imai K, Hashizume K. Generation and purification recombinant bovine pregnancy-associated glycoprotein. Vet J 2004, 168: 328.

  18. Patel OV, Yamada O, Kizaki K, Todoroki J, Takahashi T, Imai K, Schuler LA, Hashizume K. Temporospatial expression of placental lactogen and prolactin-related protein-1 genes in the bovine placenta and uterus during pregnancy. Mol Reprod Dev. 2004, 69:146.

  19. Patel OV, Takahashi T, Imai K, Hashizume K. Characterization of native and recombinant bovine pregnancy-associated glycoproteins. Res Vet Sci 2004, 77: 203.

  20. Patel OV, Yamada O, Kizaki K, Takahashi T, Imai K, Takahashi S, Izaike Y, Schuler LA, Takezawa T, Hashizume K. Expression of trophoblast cell-specific pregnancy-related genes in somatic cell-cloned bovine pregnancies. Biol Reprod. 2004, 70: 1114.

  21. Patel OV, Yamada O, Kizaki K, Takahashi T, Imai K, Hashizume K. Quantitative analysis throughout pregnancy of placentomal and interplacentomal expression of pregnancy-associated glycoproteins-1 and -9 in the cow. Mol Reprod Dev. 2004, 67: 257.

  22. Ishiwata H, Katsuma S, Kizaki K, Patel OV, Nakano H, Takahashi T, Imai K, Hirasawa A, Shiojima S, Ikawa H, Suzuki Y, Tsujimoto G, Izaike Y, Todoroki J, Hashizume K. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Molecular Reproduction and Development. Mol Reprod Dev. 2003, 65: 9.

  23. Takahashi T, Hirako M, Patel OV, Shimizu M, Hasegawa Y, Domeki I, Hashizume K. Plasma steroid profiles following follicle-stimulating hormone or equine chorionic gonadotropin injection in cows chronically treated with gonadotropin-releasing hormone agonist. J Vet Med Sci. 2002, 64: 731.　

  24. Hashizume K, Ishiwata H, Kizaki K, Yamada O, Imai K, Takahashi T, Patel OV, Akagi S, Shimizu M, Takahashi S, Tsujimoto G, Todoroki J and Izaike Y. Implantation and placental development in somatic cell clone recipient cows. Cloning and Stem Cells 2002, 4: 197.

  25. Yamada O, Kizaki K, Takahashi T, Imai K, Patel OV, Schuler LA and Hashizume K. Prolactin-related protein-1 at the feto-maternal interface during the implantation period in cows. Reprod. 2002, 124: 427.

 

Peer-reviewed Publications [*Graduate student, **Undergraduate student]

  1. Alula K*, Resau J, Patel OV. Chronic exposure to altered gravity during the pregnancy-to-lactation transition affects abundance of cytoskeletal proteins in the rat mammary gland. Gravitational and Space Research 2018, 6(1): 58.

  2. Alula K*, Resau J, Patel OV. Impact of g-Load Shift on Temporal Expression Pattern of Apoptosis-linked Proteins in the Rat Mammary Gland. Gravitational and Space Research 2019, 7(1), 13.

  3. Fisch A**., Reiber C**., Schroeder W., Smart R., Patel OV. Potent Suppression of Proliferation of Breast Carcinoma Cells by a Novel Anthranilic Acid Derivative. J. Drug Dev Res 2020; 12: 1

 

Presentations by mentored *Graduate and **Undergraduate students:

  1. Fugate M.**, Patel OV. (2018). Effects of supra-physiological dose of testosterone on breast cancer cells. Grand Rapids: West Michigan Regional Undergraduate Science Research Conference. [Van Andel Institute] (November 10, 2018)

  2. Velazquez A.**, Patel OV. (2018). Effects of testosterone on androgen-dependent and -independent prostate cancer cells. West Michigan Regional Undergraduate Science Research Conference. [Van Andel Institute] (November 10, 2018)

  3. Pardy L.**, Reiber C.**, Smart R, Schroeder W, Patel OV. Neoadjuvant therapy with BIBR 1532 Accelerates Senescence in Triple-Negative Breast Cancer Cells. West Michigan Regional Undergraduate Research Conference [Van Andel Institute] (November 21, 2015).

  4. Pardy L.**, Reiber C.**, Smart R, Schroeder W, Patel OV. Neoadjuvant therapy with anti-telomerase potentiates the effects of anthracycline based chemotherapy. Mid-Michigan Symposium for Undergraduate Research Experiences [MSU] (July 23, 2015).

  5. Fisch A.**, Smart R, Schroeder W, Patel OV. Potent Suppression of Proliferation of Carcinoma Cells by a Novel Non-Nucleoside Reverse Transcriptase Inhibitor. Genitourinary cancer Symposium, American Society for Clinical Oncology, Orlando FL, (February 26- March 1, 2015)

  6. Fisch, A.**, Smart, R, Schroeder, W, Patel OV. Comparison of nucleoside (AZT) and non-nucleoside (BIBR 1532) reverse-transcriptase inhibitors on triple negative breast cancer cells. West Michigan Regional Undergraduate Research Conference [Van Andel Institute] (November 15th, 2014)

  7. Reiber C.**, Fisch A**, Smart R, Schroeder W, Patel, OV. Effects of chronic low-dose anti-telomerase and chemotherapeutic drugs on breast cancer cells. Mid-Michigan Symposium for Undergraduate Research Experiences [MSU] (July 23rd, 2014).

  8. Fisch A**, Uzarski R, Smart R, Schroeder W, Patel, OV. Effect of novel telomerase inhibitor on triple-negative breast cancer cells. Mid-Michigan Symposium for Undergraduate Research Experiences at MSU (July 24th, 2013).

  9. K. Gebre-Egziabher*, J. Resau, K. Plaut, O. Patel . Exposure to hypergravity during pregnancy and early lactation alters abundance of cytoskeletal and extracellular matrix proteins in a rat model. Annual Biomedical Research Conference for Minority Students St. Louis, MO, (November, 2011).

  10. K. Gebre-Egziabher*, J. Resau, O. Patel. Effect of increased g-load on rat mammary gland development. 7th Annual Mich Bio Expo & Conference (November, 2011).

Page last modified February 8, 2023
Report a problem with this page