Recent publications (my undergraduate students contain an “*”):

• Powers RA, June CM, Fernando* MC, Fish* ER, Maurer* OL, Baumann* RM, Beardsley* TJ, Taracila MA, Rudin SD, Hujer KH, Hujer AM, Santi N, Villamil V, Luisa Introvigne M, Prati F, Caselli E, Bonomo RA, Wallar BJ. (2023) Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. Journal of Medicinal Chemistry, Jul 13;66(13):8510-8525. doi: 10.1021/acs.jmedchem.3c00144. PMID: 37358467 PMCID: PMC10350917.
• Introvigne ML, Beardsley* TJ, Fernando* MC, Leonard DA, Wallar BJ, Rudin SD, Taracila MA, Rather PN, Colquhoun JM, Song S, Fini F, Hujer KM, Hujer AM, Prati F, Powers RA, Bonomo RA, Caselli E. (2023) Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii. Antibiotics (Basel). Mar 24;12(4): 644. doi: 10.3390/antibiotics12040644. PubMed PMID: 37107006; PubMed Central PMCID: PMC10135033.
• Hujer, A. M., Hujer, K. M., Leonard, D. A., Powers, R. A., Wallar, B. J., Mack, A. R., Taracila, M. A., Rather, P. N., Higgins, P. G., Prati, F., Caselli, E., Kreiswirth, B. N., Fouts, D. E., & Bonomo, R. A. (2021) A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii. Diagnostic Microbiology & Infectious Disease, Feb;99(2):115242. doi: 10.1016/j.diagmicrobio.2020.115242
• Curtis*, B. N., Smolen*, K. A., Barlow*, S. J., Caselli, E., Prati, F., Taracila, M. A., Bonomo, R. A., Wallar, B. J., & Powers, R. A. (2020). Structural insights into inhibition of the Acinetobacter derived cephalosporinase ADC-7 by ceftazidime and its boronic acid transition state analog. Antimicrobial Agents and Chemotherapy 64(12):1-13, doi: 10.1128/AAC.01183-20
• Caselli, E., Fini, F., Introvigne, M. L., Stucchi, M., Taracila, M. A., Fish*, E. R., Smolen*, K. A., Rather, P. N., Powers, R. A., Wallar, B. J., Bonomo, R. A., Prati, F. (2020) 1,2,3-Triazolylmethaneboronate: a Structure Activity Relationship Study of a New Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase (ADC-7).  ACS-Infect Dis. 6(7):1965-1975.
• Bouza*, A. A.; Swanson*, H. C.; Smolen*, K. A.; VanDine*, A. L.; Taracila, M. A.; Romagnoli, C.; Caselli, E.; Prati, F.; Bonomo, R. A.; Powers, R. A.; Wallar, B. J., (2018) Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase. ACS Infect Dis 4 (3), 325-336. DOI: 10.1021/acsinfecdis.7b00152.
• Caselli, E.; Romagnoli, C.; Powers, R. A.; Taracila, M. A.; Bouza*, A. A.; Swanson*, H. C.; Smolen*, K. A.; Fini, F.; Wallar, B. J.; Bonomo, R. A.; Prati, F., (2018) Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel beta-Lactamase Inhibitors. ACS Infect Dis 4 (3), 337-348. DOI: 10.1021/acsinfecdis.7b00153.
• Powers, R. A.; Swanson*, H. C.; Taracila, M. A.; Florek*, N. W.; Romagnoli, C.; Caselli, E.; Prati, F.; Bonomo, R. A.; Wallar, B. J., (2014) Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii. Biochemistry 53 (48), 7670-9. DOI: 10.1021/bi500887n.

Recent presentations (my undergraduate students contain an “*”):

• Wallar, B.J., June, CM, Ziegler*, ZX, Jarvis*, HR, Taracila, MA, Hujer, KM, Hujer, AM, Rudin, SD, Bethel, CR, Bonomo, RA, Powers, RA. (2024) “Conformational changes in Acinetobacter-derived cephalosporinase (ADC) variants lead to enhanced cephalosporinase activity in Acinetobacter baumannii; two mechanisms of deacylation” 34th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain.
• Ziegler*, Z.X., June, C.M., Caselli, E., Prati, F., Powers, R. A., Wallar, B. J. (2023) Characterization of inhibitors of ADC-33, a β-lactamase variant involved in antibiotic resistance. 43^rd Midwest Enzyme Chemistry Conference, Northwestern University.
• Ziegler*, Z.X., June, C.M., Caselli, E., Prati, F., Powers, R. A., Wallar, B. J. (2023) Characterization of inhibitors of ADC-33, a β-lactamase variant involved in antibiotic resistance. West Michigan Regional Undergraduate Science Research Conference, Van Andel Institute.
• Fergus*, M. D., Pierce*, L. R., June, C. M., Caselli, E., Prati, F., Wallar, B. J., Powers, R. A. ACS Spring 2023 Meeting, American Chemical Society, Indianapolis, IN, "Exploring Cross-Class Inhibition of Key Antibiotic Resistance Targets in the Multidrug Resistant Pathogen Acinetobacter baumannii", Academic. (March 27, 2023).
• Baumann*, R.M., Bengston*, J.E., Maurer*, O. L., Fernando*, M. C, Hujer, A. M., Bonomo, R. A., Powers, R. A Wallar, B. J. (2022) Structural and functional analysis of novel ADC variants from carbapenem-resistant Acinetobacter baumannii. 42^nd Midwest Enzyme Chemistry Conference, Loyola University, Chicago.
• Fergus*, M.D., Pierce*, L.R., Caselli, E., Prati, F., Wallar, B. J., Powers, R. A. (2022) Exploring cross-class C and D β-lactamase inhibition of novel boronic acids. 42^nd Midwest Enzyme Chemistry Conference, Loyola University, Chicago.
• Baumann*, R.M., Bengston*, J.E, Powers, R.A, Wallar, B. J. (2022) Characterization of new inhibitors of ADC-30: combatting a clinically relevant variant involved in antibiotic resistance. GVSU Summer Showcase. GVSU, Allendale, MI.
• Maurer*, O. L., Fernando*, M. C., Fish*, E. R., Hujer, A. M., Bonomo, R. A., Powers, R. A., Wallar, B. J. (2021) Structural and functional characterization of novel ADC variants contributing to antibiotic resistance. 41^st Midwest Enzyme Chemistry Conference, Virtual.
• Beardsley*, T. J., Fernando, M.C., Fish*, E. R., June, C.M., Rather, P.N., Caselli, E., Prati, F., Hujer, A. M., Bonomo, R. A., Powers, R., Wallar, B.J. (2021) Kinetic and structural characterization of ADC variants from carbapenem-resistant Acinetobacter baumannii World Microbe Forum, June 20-24, iPoster WMF21-3101.
• Fernando*, M. C., Beardsley*, T. J., Fish*, E. R., Hujer, A. M., Bonomo, R. A., Powers, R., Wallar, B.J.. (2020) Kinetic and structural characterization of novel ADC variants from carbapenem-resistant Acinetobacter baumannii 40^th Midwest Enzyme Chemistry Conference, Virtual.
• Ruiz*, V.J., Fernando*, M.C., Fish*, E.R., Caselli, E., Prati, F., Hujer, A.M., Bonomo, R.A., Powers, R.A., Wallar, B.J. (2020) Kinetic and structural characterization of ADC variants from carbapenem resistant Acinetobacter baumannii. ASM Microbe, June 18-22, Chicago, IL (conference cancelled).
• June, C.M., Curtis*, B.N., Caselli, E., Prati, F., Bethel, C.R., Bonomo, R.A., Wallar, B.J., Leonard, D.A., Powers, R.A. (2020) X-ray crystal structure of the carbapenem-hydrolyzing class D b-lactamase OXA-24/40 in complex with a ceftazidime-like boronic acid inhibitor. ASM Microbe, June 18-22, Chicago, IL (conference cancelled).
• Caselli, E., Introvigne, M.L., Fini, F., Taracila, M.A., Fish*, E.R., Smolen*, K.A., Rather, P., Powers, R.A., Wallar, B.J., Bonomo, R.A., Prati, F. (2020) 1,2,3-Triazolylmethaneboronate: a SAR study of a New Class of β-Lactamase Inhibitors in Acinetobacter baumannii. ASM Microbe, June 18-22, Chicago, IL (conference cancelled).
• Fish*, E. R., Caselli, E., Taracila, M.A., Bonomo, R. A., Prati, F., Powers, R., Wallar, B. J. (2019) Characterization of Novel Triazole-Containing Boronic Acid Transition State Inhibitors (BATSIs) of Acinetobacter-derived Cephalosporinase (ADC-7). Protein Society Annual Meeting, Seattle, WA.
• Curtis*, B. N., Caselli, E., Taracila, M.A., Bonomo, R. A., Prati, F., Powers, R., Wallar, B. J. (2019) Structural Characterization of Acinetobacter-Derived Cephalosporinase-7 in Complex With Ceftazidime and its Transition State Analog. Protein Society Annual Meeting, Seattle, WA.
• Fish*, E. R., Curtis*, B. N., Smolen*, K. A., Caselli, E., Prati, F., Powers, R., Wallar, B. J. (2018) Structure-based analysis of inhibitors of Acinetobacter-derived cephalsporinase-7 (ADC-7), a unique class C β-lactamase. 38^th Midwest Enzyme Chemistry Conference, Northwestern University, Evanston, IL.
• Taracila, M.A., Caselli, E., Prati, F., Powers, R.A., Wallar, B.J., Bonomo, R.A. (2017) Active Site Interactions of Boronic Acid Inhibitors of Acinetobacter-Derived Cephalosporinase (ADC-7) Class C β-lactamases-Lessons for New Drug Design.  American Society for Microbiology – Annual “Microbe” Conference, New Orleans, LA.
• Wallar, B.J., Prati, F., Caselli, E., Romagnoli, C., Swanson*, H.C., Bouza*, A., VanDine*, A., Bonomo, R.A., Powers, R.A. (2015) Exploring the structure-activity relationship of a series of boronic acid inhibitors of Acinetobacter-derived cephalosporinase ADC-7.  55^th  Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA.
• Powers, R.A., Prati, F., Caselli, E., Romagnoli, C., Swanson*, H.C., Bouza*, A., Smolen*, K., Bonomo, R.A., Wallar, B.J. (2015) Structure-function analysis of R2 substituents in boronic acid inhibitors of Acinetobacter-derived cephalosporinase (ADC-7). 55^th  Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA.
• Swanson*, H. C., Prati, F., Caselli, E., Romangoli, C., Taracila, M. A., Bonomo, R. A., Powers, R., Wallar, B.J. (2014) X-ray crystal structure of the extended-spectrum class C β-lactamase, ADC-7, in apo form and in complex with a boronic acid transition state analog. American Chemical Society Annual Meeting, Dallas, TX.
• Wallar, B.J., Prati, F., Caselli, E., Romangoli, C., Swanson*, H. C., Taracila, M. A., Bonomo, R. A., Powers, R. (2013) Acinetobacter spp. class C cephalosporinase (ADC-7) is inhibited by boronic acid transition state analogs. 53^rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Denver, CO.
• Baggett*, V.L., Docter*, B.E., Leonard, D., Powers, R., Wallar, B.J. (2013) The N152T mutation in the class C β-lactamase, AmpC, can serve as a substrate selectivity switch. American Society for Biochemistry and Molecular Biology Annual Meeting, Boston, MA.
• Porambo*, A. R., Florek*, N., Powers, R., Wallar, B.J. (2013) The X-ray crystal structure of the Acinetobacter-Derived Cephalosporinase, ADC-7. American Society for Biochemistry and Molecular Biology Annual Meeting, Boston, MA.
• Docter*, B.E., Anwar, M., Leonard, D., Powers, R., Wallar, B.J.  (2013) Probing the binding site in the antibiotic resistance enzyme, AmpC, β-lactamase.  Enzyme Mechanisms Conference, Coronado, CA.