Viviane Corrêa Santos
Assistant Professor of Chemistry
Office: 353 Padnos
Phone: 331-3778
Email: [email protected]
Education/Professional Training
PhD Biochemistry, Universidade Federal De Minas Gerais, Brazil
MSc, Biochemistry & Immunology, Universidade Federal De Minas Gerais, Brazil
BSc, Pharmacy, Universidade Federal De Minas Gerais, Brazil
Research Interests
- Drug discovery
- Computer-aided drug design
- Enzymatic assays
- Proteases
- Chagas Disease
Chagas Disease is a Neglected Tropical Disease endemic to the American continent. The causative agent of Chagas Disease is the parasite Trypanosoma cruzi. There are only two FDA-approved drugs to treat this condition, both with limited efficacy and several side effects. Therefore, there is an urgent need to develop new treatments. My research focuses on using the proteases of T. cruzi as targets for drug development, employing a combination of experimental and computational approaches.
Publication highlights:
Viviane Corrêa Santos, Paulo Gaio Leite, Lucianna Helene Santos, Pedro Geraldo Pascutti, Peter Kolb, Fabiana Simão Machado, Rafaela Salgado Ferreira, Structure-based discovery of novel cruzain inhibitors with distinct trypanocidal activity profiles, European Journal of Medicinal Chemistry, https://doi.org/10.1016/j.ejmech.2023.115498.
Viviane Corrêa Santos, Antonio Edson Rocha Oliveira, Augusto César Broilo Campos, João Luís Reis-Cunha, Daniella Castanheira Bartholomeu, Santuza Maria Ribeiro Teixeira, Ana Paula C. A. Lima, Rafaela Salgado Ferreira, The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites, Scientific Reports, https://doi.org/10.1038/s41598-021-97490-2.
Complete publication list